Reduced overeating, increased appreciation: The impact of GLP-1s on Thanksgiving

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  • Last update: 11/29/2025
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Over 46 million turkeys are consumed each Thanksgiving, accompanied by side dishes and desserts that often pack a days worth of calories into a single meal. For millions of people taking GLP-1 medications, which reduce appetite and curb cravings, enjoying the holiday feast can look very different. These drugs make it easier to skip second helpings, prompting questions about how to approach traditional holiday meals.

Adjusting Portions Without Sacrificing Nutrition

GLP-1 medications slow digestion and gastric emptying, signaling fullness sooner. Sugary, fatty, or heavy foods like mashed potatoes, gravy, and pies can cause discomfort for those on these medications. Registered dietitian Amy Goodson emphasizes prioritizing nutrients: "Anchor your plate with protein such as turkey or ham, add vegetables, and consider smaller portions of carb-heavy dishes." Dessert is still possible, but she suggests saving some carbohydrates for it.

Sabrina, a 38-year-old mother, recalls her first Thanksgiving on Mounjaro. Unsure whether to skip her injection to boost her appetite, she discovered through online discussions that continuing the medication was best. "Youre not supposed to come off your medication to overindulge," she explains. She enjoyed her meal without overdoing it and simply brought home leftovers.

Modifying Traditions

For first-time GLP-1 users, bringing personal dishes as a backup can help avoid discomfort. Dr. Karla Lester, a pediatric and obesity medicine specialist, notes most patients can still enjoy traditional meals if they eat smaller portions. She also recommends having snacks throughout the day rather than fasting for a large dinner.

Michael Donnelly-Boylen adapted his potluck-style Thanksgiving after starting GLP-1 treatment. He swapped candied sweet potatoes for lightly seasoned ones and reduced the amount of his signature bread stuffing. "Now I enjoy the flavor without the sugar and breadits very freeing," he says.

Navigating Family Conversations

Holidays can bring family pressure and weight-related comments. Research shows over 40% of American adults have faced weight stigma. Lester advises setting boundaries and responding neutrally to remarks about food or body size.

For some, GLP-1 use has improved family interactions. Donnelly-Boylen shares, "Being on the medication eased the focus on my weight; my family was more concerned about my health, which made Thanksgiving more enjoyable."

Focusing on Family Over Food

GLP-1 medications have helped both Sabrina and Donnelly-Boylen concentrate on social connections rather than overeating. Sabrina notes a reduction in migraines, likely due to lower inflammation from the medication, and appreciates her familys support for healthier choices. Donnelly-Boylen explains that last Thanksgiving, "It became about family and not food, which was freeing. My mind engaged in conversation instead of scanning the table."

Addition from the author

Analysis: Navigating Thanksgiving with GLP-1 Medications

The widespread use of GLP-1 medications is reshaping traditional holiday eating patterns. These drugs, which reduce appetite and slow gastric emptying, help users avoid overindulging during calorie-dense meals without compromising nutrition. Practical adjustments, such as prioritizing protein and vegetables and moderating carbohydrate portions, allow patients to enjoy Thanksgiving staples while minimizing discomfort.

Real-life experiences underscore the importance of planning. Individuals like Sabrina and Michael adapted their meals by continuing their medications, adjusting recipes, and bringing personal dishes. These strategies demonstrate that the holiday can remain enjoyable without overriding medical guidance or personal health goals.

Equally significant is the social aspect. GLP-1 use can shift family dynamics, reducing focus on weight and fostering more supportive interactions. By emphasizing smaller portions, balanced meals, and mindful eating, users report enhanced enjoyment of family gatherings and a healthier approach to traditional holiday celebrations.

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Author: Sophia Brooks

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